Supplemental Information Stimulation of Nipah Fusion: Small Intradomain Changes Trigger Ex- tensive Interdomain Rearrangements

On Reducing the Impact of Interdomain Route Changes

Interdomain route changes are frequent and they can have negative impact on a network’s operation: during route convergence, packets get delayed and dropped; after route convergence, changes in the egress point for reaching a destination can alter the network’s intradomain traffic patterns and trigger new traffic-engineering. In this paper, we look into reducing the impact of interdomain route ...

I-44: Mutagenesis during Embryogenesis

We developed several novel tools to genome wide screen for CNVs and SNPs in single cells. When applied to cleavage stage embryos from young fertile couples we discovered, unexpectedly, an extremely high incidence of chromosomal instability, a hallmark of tumorigenesis (Vanneste et al., Nature Medicine, 2009; Vanneste et al., Hum.Reprod., 2011). Not only mosaicisms for whole chromosome aneuploid...

Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins.

Proteins with similar crystal structures can have dissimilar rates of substrate binding and catalysis. Here we used molecular dynamics simulations and biochemical analysis to determine the role of intradomain and interdomain motions in conferring distinct activation rates to two Gα proteins, Gα(i1) and GPA1. Despite high structural similarity, GPA1 can activate itself without a receptor, wherea...

Routage intradomaine et interdomaine dans les réseaux de coeur. (Intradomain and interdomain routing in backbone networks)

Traffic Engineering Between Neighboring Domains

Network operators control the flow of traffic in today’s IP networks by manipulating the configuration of the routing protocols running on their routers. Although intradomain traffic engineering is largely isolated to individual Autonomous Systems (ASes), changes to interdomain routing policies affect the traffic load in other domains. In this paper, we argue that neighboring ASes should cooper...